Definition

All of malformations, very rare, which is done according to autosomal recessive transmission (it is sufficient that one of the two parents pass genetic anomaly that the child has the disease) and whose prognosis is often fatal. Symptoms Statural delay (insufficient growth) Malformations of fingers and toes (lack of development of the inch and the first metatarsals: bones between the ankle and toes). These malformations of fingers are sometimes accompanied by an absence of the Middle phalanx of the index, the phalanges of the first toe and phalanges who complete the other toes (distal phalanges). Lack of development of the clavicles Anomalies of features of the face: the face is not sufficiently developed and is accompanied by a micrognathia (undersized jaw). The philtrum (part of the face between the base of the nose and upper lip) is also abnormal. Fontanelles (spaces between the bones of the skull of the infant and the infant, that ossifient gradually) and expanded cranial sutures (immobile joints whose skull parts are connected by a fibrous tissue). Sparse hair eyebrows and sparse eyelashes expanded and discarded pinna lips thin evolution generally, children with this syndrome are cardiac and respiratory problems characterized by an increase in volume of the heart muscle. BIBLIO Yunis E, Varon H cléidocranial dysostosis sever micrognathia, bilateral absence of thumbs and first metatarsal bone and distal aphalanja. Am I say Child, 1980,134: 649-653.