ATENOLOL 50 mg IREX Atenolol 50 mg scored tablets Action
Beta blockers. In General, and beta-blockers are used to reduce blood pressure, reduce the disorders of the heart rate, slow the c? ur and thus make savings on its operation. For all these reasons, they are also used in coronary failure.
The angiogram is a substance that has the ability to bind to receptors called beta receptors or adrenoceptors (see below).
Β-blockers may have side effects on the pulmonary tree, such as bronchoconstriction (asthma). They are therefore contraindicated in asthma. There is an interaction between β-blockers, the sympathetic system and thus the regulation of blood glucose is disrupted, leading to a hypoglycaemia. This molecule tends to become more cardiosélective (exclusive action on the Beta1 receptors in the c? ur).
It also distinguishes β-blockers by their intrinsic sympathomimetic (ASI) activity or not. The presence of intrinsic sympathomimetic activity is responsible for lower bradycardia lesser resting, to a lesser of effect bronchoconstricteur or vasoconstrictor and least metabolic disturbance. This variety of β-blockers is ineffective for migraine headaches.

Indications
• High blood pressure
• Myocardial infarction
• Angina

Contraindications
• Pure Prinzmetal Angina
• Asthma
• High degree non-left atrioventricular block
• Significant bradycardia (less than 40 beats per minute)
• Pregnancy and breastfeeding (of β-blockers may be prescribed if necessary after medical consensus). It does not exist, apparently known teratogenic effect. It must nevertheless monitor the baby the first 5 days: blood sugar, frequency and respiratory status, heart rate
• Orthostatic hypotension
• Uncompensated heart failure
• Sick sinus including sinoatrial block
• Untreated pheochromocytoma
• Syndrome of Raynaud and peripheral arterial disorders in their severe forms

Adverse effects
• Asthenia early treatment
• Asthma
• Severe bradycardia
• Nightmares and insomnia
• Skin diseases
• Diarrhea
• Gastralgies
• Hypoglycemia
• Low blood pressure
• Orthostatic hypotension
• Heart failure
• Nausea
• Paresthesia of the extremities
• Raynaud’s syndrome
• Vomiting
Acute poisoning is responsible for a decrease in blood pressure, slow heart rate and the electrical conduction between the atrium and ventricle.

Dosage
• Hypertension: 100 mg per day in the morning
• Angina: 100-200 mg per day

Precautions and use
Never discontinue treatment, especially when there are angina pectoris, because there is a risk of myocardial infarction, serious disorders of heart rhythm and sudden death.
• Dosage should be reduced in renal failure
• Monitored for signs of heart, especially when failure it said of the history of this type, particularly in the elderly
• In the diabetic patient: the signs announcing a hypoglycemia, such as palpitations and sweats, can be hidden. It is best to use cardiosélectif beta blockers and strengthen Glycemic controls at the beginning of the treatment.
• Use of β-blockers should be done with caution when there is a first degree atrioventricular block.
• For pheochromocytoma, always associate an alpha blocker to prevent hypertensive crisis
• Precautions in the presence of a chronic obstructive bronchopathie and history of bronchospasm
• Patients with Raynaud’s syndrome will have to take of β-blockers only after medical consensus.
• Molecule to be used with caution when there is history of anaphylactic shock
• Presence of renal or hepatic failure, it is preferable to favour a beta blocker that is not eliminated by the insufficient body or reduce the dosage.
• In general anaesthesia, it is recommended to stop 48 hours before treatment or providing an atropine premedication if necessary.

Drug interactions
• Amiodarone
• Halogenated volatile anesthetics
Antacids •
• Tricyclic antidepressants
• Antidiabetic
Non-steroidal anti-inflammatory •
• Bepridil
• Cimetidine
• Corticosteroid
• Dilthiazem
• Disopyramide
• Floctafénine
• Lidocaine
• Liorésat
• Mefloquine
• Neuroleptic
• Nifedipine
• Iodinated contrast
• Quinidinique
• Sultopride
• Tacrine (risk of excessive bradycardia)
• Verapamil